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About 90 percent of a dose of Testosterone is excreted in the urine as glucuronic and sulfuric acid conjugates of Testosterone and its metabolites; about 6 percent of a dose is excreted in the feces, mostly in the unconjugated form. Inactivation of Testosterone occurs primarily in the liver. Testosterone is metabolized to various 17-keto steroids through two different pathways. The half-life of Testosterone cypionate when injected intramuscularly is approximately eight days. In many tissues the activity of Testosterone appears to depend on reduction to dihydroTestosterone, which binds to cytosol receptor proteins. The steroid-receptor complex is transported to the nucleus where it initiates transcription events and cellular changes related to androgen action. Indications and Usage for Testosterone. Testosterone cypionate injection is indicated for replacement therapy in the male in conditions associated with symptoms of deficiency or absence of endogenous Testosterone. Primary hypogonadism (congenital or acquired)-testicular failure due to cryptorchidism, bilateral torsion, orchitis, vanishing testis syndrome; or orchidectomy. Hypogonadotropic hypogonadism (congenital or acquired)-gonadotropin or LHRH deficiency, or pituitary-hypothalamic injury from tumors, trauma, or radiation. Safety and efficacy of Testosterone cypionate injection in men with ‘age’-related hypogonadism’ (also referred to as ‘late-onset hypogonadism’) have not been established. Known hypersensitivity to the drug 2. Males with carcinoma of the breast 3, buy anadrol 50 mg oral steroids $87.00 anadrol, oxy. Males with known or suspected carcinoma of the prostate gland 4. Women who are pregnant (see PRECAUTIONS, Pregnancy) 5. Patients with serious cardiac, hepatic or renal disease (see WARNINGS) Warnings. Hypercalcemia may occur in immobilized patients. If this occurs, the drug should be discontinued. 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